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陈甲,秦鲁平,罗猛,赵明,陈蕾,吴涛,邓本强*.慢性脑低灌注性血管性认知损害患者血清p75神经营养素受体细胞外段水平及其与炎性因子的关系[J].Academic Journal of Second Military Medical University ,2019,40(6):602-607
慢性脑低灌注性血管性认知损害患者血清p75神经营养素受体细胞外段水平及其与炎性因子的关系    点此下载全文 Fulltext
陈甲  秦鲁平  罗猛  赵明  陈蕾  吴涛  邓本强*
海军军医大学(第二军医大学)
长海医院脑血管病中心, 上海 200433
*通信作者
基金项目:上海市科委医学引导类项目(124119a8900).
DOI:10.16781/j.0258-879x.2019.06.0602
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摘要:
      目的 检测慢性脑低灌注性血管性认知损害(CCH-VCI)患者血清p75神经营养素受体细胞外段(p75NTR-ECD)水平,并探讨其与肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-1β、IL-6的关系。方法 选择海军军医大学(第二军医大学)长海医院2018年8月至12月收治的34例CCH-VCI患者,以及同期相同年龄段的36名中老年健康人和34例缺血性脑卒中患者作为研究对象。采用酶联免疫吸附试验测定3组研究对象的血清p75NTR-ECD、TNF-α、IL-1β、IL-6水平并进行组间比较。采用Spearman相关分析研究CCH-VCI患者血清p75NTR-ECD水平与TNF-α、IL-1β、IL-6水平的相关性。结果 CCH-VCI组血清p75NTR-ECD水平高于健康对照组和缺血性脑卒中组[(544.36(440.88,628.50)pg/mL vs 276.49(262.59,313.87)pg/mL、366.87(337.09,450.43)pg/mL],差异均有统计学意义(U=87.500、335.500,P均<0.05)。CCH-VCI组患者血清TNF-α、IL-1β、IL-6水平分别为196.02(141.20,280.35)pg/mL、68.23(60.79,91.94)pg/mL、51.04(40.24,65.26)pg/mL,缺血性脑卒中组分别为218.67(143.76,281.28)pg/mL、76.87(59.10,99.91)pg/mL、64.45(43.13,86.76)pg/mL,均分别高于健康对照组[分别为73.71(56.94,79.81)pg/mL、42.98(34.52,51.34)pg/mL、14.97(11.76,21.19)pg/mL],差异均有统计学意义(U=31.000、4.000,106.000、132.000,48.000、13.000;P均<0.05)。CCH-VCI患者血清p75NTR-ECD水平与TNF-α水平存在相关性(r=0.391,P=0.022),但与IL-1β和IL-6水平均无明显相关性(r=0.032、0.164,P=0.855、0.355)。结论 慢性脑低灌注损伤后p75NTR可能与TNF-α等炎性因子有关,并共同参与了CCH-VCI的发病。
关键词:脑低灌注  血管性认知损害  p75神经营养素受体细胞外段  炎性因子
Serum p75 neurotrophin receptor-extracellular domain level and its relationship with inflammatory factors in patients with chronic cerebral hypoperfusion-vascular cognitive impairment    Fulltext
CHEN Jia  QIN Lu-ping  LUO Meng  ZHAO Ming  CHEN Lei  WU Tao  DENG Ben-qiang*
Stroke Center, Changhai Hospital, Naval Medical University(Second Military Medical University)
, Shanghai 200433, China
*Corresponding author
Fund Project:
Abstract:
      Objective To investigate serum p75 neurotrophin receptor-extracellular domain (p75NTR-ECD) level in patients with chronic cerebral hypoperfusion-vascular cognitive impairment (CCH-VCI) and its relationship with tumor necrosis factor α (TNF-α), interleukin (IL)-1β and IL-6. Methods The clinical data of patients with CCH-VCI (n=34) were collected from Changhai Hospital, Naval Medical University (Second Military Medical University) from Aug. to Dec. 2018. Enzyme linked immunosorbent assay was applied for detection of serum levels of p75NTR-ECD, TNF-α, IL-1β and IL-6; and the results were then compared with those of ischemic stroke participants (n=34) and healthy controls (n=36), who were all in the same age range. Spearman correlation analysis was used to analyze the relationship between serum p75NTR-ECD level and the above-mentioned inflammatory factors in CCH-VCI patients. Results The serum p75NTR-ECD level in the CCH-VCI group was significantly higher than those in the healthy control group and the ischemic stroke group (544.36[440.88, 628.50] pg/mL vs 276.49[262.59, 313.87] pg/mL and 366.87[337.09, 450.43] pg/mL, U=87.500 and 335.500, both P<0.05). The serum levels of TNF-α, IL-1β and IL-6 were 196.02 (141.20, 280.35) pg/mL, 68.23 (60.79, 91.94) pg/mL and 51.04 (40.24, 65.26) pg/mL in the CCH-VCI group, respectively, and 218.67 (143.76, 281.28) pg/mL, 76.87 (59.10, 99.91) pg/mL and 64.45 (43.13, 86.76) pg/mL in the ischemic stroke group, respectively, which were all significantly higher than those in the healthy control group (73.71[56.94, 79.81] pg/mL, 42.98[34.52, 51.34] pg/mL and 14.97[11.76, 21.19] pg/mL, respectively; U=31.000 and 4.000, 106.000 and 132.000, and 48.000 and 13.000; all P<0.05). Serum p75NTR-ECD level in the CCH-VCI patients was correlated with TNF-α level (r=0.391, P=0.022), but not with IL-1β or IL-6 levels (r=0.032 and 0.164, P=0.855 and 0.355). Conclusion Serum p75NTR level may be related to inflammatory factors (TNF-α) after chronic cerebral hypoperfusion, and they may jointly participate in the pathogenesis of CCH-VCI.
Keywords:cerebral hypoperfusion  vascular cognitive impairment  p75 neurotrophin receptor-extracellular domain  inflammatory factor
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