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  • 李玉莉,王国俊,甘乐文.氧化苦参碱对大鼠肝纤维化的影响[J].第二军医大学学报,1999,20(7):    [点击复制]
  • 李玉莉,王国俊,甘乐文.Effects of oxymatrine on liver fibrosis in rats[J].Acad J Sec Mil Med Univ,1999,20(7):   [点击复制]
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氧化苦参碱对大鼠肝纤维化的影响
李玉莉,王国俊,甘乐文
0
()
摘要:
目的:探讨氧化苦参碱对实验性肝损伤肝胶原合成度及纤维化的影响。方法:采用CCl4造成大鼠慢性肝损伤肝纤维化模型,同时用氧化苦参碱防治,并动态观察血清丙氨酸氨基转移酶(ALT)、Ⅳ型胶原(Ⅳ-C)、透明质酸(HA)、肿瘤坏死因子-α(TNFα)的水平及肝组织病理变化,通过计算机图像分析系统分析肝内纤维组织增生情况。结果:氧化苦参碱治疗组血清ALT,Ⅳ-C,HA,TNFα水平及肝组织内炎症活动度、纤维组织增生程度均低于模型组,且大剂量治疗组又低于小剂量治疗组。结论:氧化苦参碱有减轻肝脏炎症活动度、抑制肝内胶原合成度及抗肝纤维化作用。
关键词:  氧化苦参碱  四氯化碳  肝纤维化
DOI:
基金项目:
Effects of oxymatrine on liver fibrosis in rats
李玉莉,王国俊,甘乐文
()
Abstract:
Objective: To evaluate the effects of oxymatrine on liver fibrosis. Methods: Chronic liver damage and liver fibrosis in rats were induced by hypodermically injecting carbon tetrachloride (CCl4) twice a week for 12 weeks, and were simultaneously treated intraperitoneally with oxymatrine once a day. The levels of serum alanine aminotransferase (ALT), type IV collagen (Ⅳ-C), hyaluronate (HA), tumor necrosis factor alpha (TNFα) were detected at various times, and the degrees of inflammatory activity and fibrogenesis in liver tissues were also observed. Results: The levels of serum ALT, IV-C, HA, and TNFα were lower in the oxymatrine-treated rats than those in the oxymatrine-untreated ones, and so were the degrees of inflammatory activity and fibrogenesis in liver tissues. Conclusion: Oxymatrine can inhibit the inflammatory activity and fibrogenesis in liver tissue.
Key words:  oxymatrine  carbon tetrachloride  liver fibrosis