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  • 查旭东,王雯雯,王明宇,商学军.空气污染对妊娠期并发症的影响及其机制[J].第二军医大学学报,2019,40(5):567-572    [点击复制]
  • CHA Xu-dong,WANG Wen-wen,WANG Ming-yu,SHANG Xue-jun.Effect of air pollution on complications during pregnancy and its mechanism[J].Acad J Sec Mil Med Univ,2019,40(5):567-572   [点击复制]
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空气污染对妊娠期并发症的影响及其机制
查旭东1,王雯雯1,王明宇1,商学军2*
0
(1. 海军军医大学(第二军医大学)基础医学院学员五队, 上海 200433;
2. 解放军东部战区总医院男科, 南京 210002
*通信作者)
摘要:
女性妊娠期健康受多种环境和行为因素的影响。空气污染是一种重要的外暴露环境因素,已有多项研究分析了空气污染对女性妊娠期并发症的影响,大多数研究结果显示空气污染与妊娠期糖尿病(GDM)和妊娠期高血压疾病(HDP)的发病率升高有关。空气中的颗粒物和气溶胶污染物成分可通过炎症反应、氧化应激及其他机制导致GDM和HDP发生。孕前控制体质量指数,补充叶酸、维生素D等微量元素,对妊娠期并发症的预防起积极作用。本文综述了空气污染物中各成分对妊娠期并发症的具体影响及可能机制,为妊娠期并发症的预防提供参考。
关键词:  空气污染  妊娠性高血压  妊娠糖尿病  氧化性应激  炎症
DOI:10.16781/j.0258-879x.2019.05.0567
投稿时间:2019-03-20修订日期:2019-05-14
基金项目:国家重点研发计划重点专项(2018YFC1004300).
Effect of air pollution on complications during pregnancy and its mechanism
CHA Xu-dong1,WANG Wen-wen1,WANG Ming-yu1,SHANG Xue-jun2*
(1. The Fifth Student Team, College of Basic Medical Sciences, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Andrology, General Hospital of PLA Eastern Theater Command, Nanjing 210002, Jiangsu, China
*Corresponding author)
Abstract:
Pregnant women's health is vulnerable to a variety of environmental and behavioral factors. Air pollution is one of the important environmental factors for pregnant women, and many studies have analyzed its impact on complications during pregnancy. Most of the findings demonstrate that air pollution is associated with the increased incidence of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). The particles and aerosol contaminants in the air can cause GDM and HDP through inflammation, oxidative stress, and other mechanisms. To control body mass index before pregnancy and supplement trace elements such as folic acid and vitamin D play active roles in preventing complications during pregnancy. In this review, we discussed the effects of various components of air pollutants on complications during pregnancy, hoping to provide references for preventing complications during pregnancy.
Key words:  air pollution  pregnancy-induced hypertension  gestational diabetes  oxidative stress  inflammation