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  • 韩治敏,宫春爱,强磊,李国瑞,汪小丽,高申.纳米技术应用于肿瘤免疫治疗的研究进展[J].第二军医大学学报,2019,40(5):560-566    [点击复制]
  • HAN Zhi-min,GONG Chun-ai,QIANG Lei,LI Guo-rui,WANG Xiao-li,GAO Shen.Application of nanotechnology in immunotherapy of cancer: an advance[J].Acad J Sec Mil Med Univ,2019,40(5):560-566   [点击复制]
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纳米技术应用于肿瘤免疫治疗的研究进展
韩治敏1,宫春爱2,强磊1,李国瑞1,汪小丽3,高申1*
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(1. 海军军医大学(第二军医大学)长海医院药学部, 上海 200433;
2. 上海交通大学医学院附属第九人民医院药剂科, 上海 200011;
3. 安徽省军区马鞍山离职干部休养所, 马鞍山 243000
*通信作者)
摘要:
近年来,人们对肿瘤生物学和免疫学的基本原理有了更深入的了解,肿瘤的免疫治疗已经取得重大进展,极大促进了一系列新免疫治疗肿瘤药物的发展。肿瘤免疫治疗是指重新启动人体自身免疫系统消除肿瘤细胞。然而,免疫调节化合物系统传递的安全性和有效性问题限制了肿瘤免疫疗法的推广与应用。纳米技术由于其独特的优点,如靶向性好、不良反应少、稳定性好,各种具有不同理化特性的纳米靶向递送体系被开发出来,以刺激免疫系统实现抗肿瘤治疗。本文就近年来纳米技术联合免疫治疗肿瘤的研究进展作一综述。
关键词:  免疫治疗  纳米技术  肿瘤  癌症疫苗  单克隆抗体
DOI:10.16781/j.0258-879x.2019.05.0560
投稿时间:2019-01-02修订日期:2019-02-22
基金项目:国家自然科学基金(81672516),上海市科委基础研究项目(18JC1414200),国家临床重点专科-临床药学军队建设项目,上海市卫生和计划生育系统重要薄弱学科建设项目(2016ZB0303).
Application of nanotechnology in immunotherapy of cancer: an advance
HAN Zhi-min1,GONG Chun-ai2,QIANG Lei1,LI Guo-rui1,WANG Xiao-li3,GAO Shen1*
(1. Department of Pharmacy, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Pharmacy, Ninth People's Hospital of Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China;
3. Maanshan Retired Cadre Sanatorium of Anhui Military Region, Maanshan 243000, Anhui, China
*Corresponding author)
Abstract:
In recent years, scientists have had a deeper understanding of the basic principles of tumor biology and immunology, and immunotherapy for cancer has made great progresses, greatly promoting the development of a series of new immunotherapy drugs for cancer. Cancer immunotherapy aims at eliminating cancer cells by stimulating and coordinating the immune system. However, the promotion and application of cancer immunotherapy are limited because of the uncertain safety and effectiveness of immune regulatory compound delivery. Due to its unique advantages, such as good targeting, less adverse events, and good stability, various nano-targeted delivery systems with different physical and chemical properties have been developed to stimulate the immune system in anti-tumor therapy. In this review, we summed up the research progresses of nanotechnology combined with immunotherapy for cancer in recent years.
Key words:  immunotherapy  nanotechnology  neoplasms  cancer vaccines  monoclonal antibodies