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  • 李翯,骆银,杨鹏飞,刘建民.缺血性脑卒中神经保护治疗的研究进展[J].第二军医大学学报,2018,39(9):1040-1046    [点击复制]
  • LI He,LUO Yin,YANG Peng-fei,LIU Jian-min.Advance in neuroprotective therapy for ischemic stroke[J].Acad J Sec Mil Med Univ,2018,39(9):1040-1046   [点击复制]
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缺血性脑卒中神经保护治疗的研究进展
李翯1,2,骆银1,杨鹏飞1*,刘建民1*
0
(1. 海军军医大学(第二军医大学)长海医院脑血管病中心, 上海 200433;
2. 海军军医大学(第二军医大学)研究生院学员二大队, 上海 200433
*通信作者)
摘要:
脑卒中是一种严重影响人类生命和生活质量的中枢神经系统疾病,全球死亡率排序位列第2位。目前缺血性脑卒中的临床治疗策略主要是静脉溶栓及机械取栓疗法,然而,这些治疗方法不能有效防止缺血引起的脑组织损伤与功能障碍,需要寻找能够有效防止脑缺血损伤与脑缺血-再灌注损伤的神经保护疗法。本文回顾了近年防治缺血性脑卒中后神经功能损伤药物,包括离子通道阻断剂、抗氧化剂、抗炎药物、凋亡抑制剂等的研究进展,对这些药物的特点和优劣进行分析,并总结了非药物神经保护疗法。
关键词:  缺血性脑卒中  神经保护  再灌注损伤  抗氧化剂
DOI:10.16781/j.0258-879x.2018.09.1040
投稿时间:2018-07-22修订日期:2018-08-19
基金项目:上海市卫生系统优秀人才培养计划(2017YQ034),上海市浦江人才计划项目(16PJD003).
Advance in neuroprotective therapy for ischemic stroke
LI He1,2,LUO Yin1,YANG Peng-fei1*,LIU Jian-min1*
(1. Stroke Center, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China;
2. The Second Student Team, Graduate School, Navy Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding authors)
Abstract:
Stroke is a central nervous system disease that seriously affects the quality of life of the victims, with the second highest mortality among all the diseases in the world. At present, the main clinical treatment strategies for acute ischemic stroke are intravenous thrombolysis and mechanical thrombectomy, whereas these strategies do not protect patients from ischemia injury and functional disorder. Therefore, it is necessary to find neuroprotective methods to ameliorate ischemic injury and ischemic/reperfusion injury. This review summed up the current studies on the drugs which prevent and treat neurologic impairment after ischemic stroke, including ion channel blocker, antioxidant, anti-inflammatory agent, anti-apoptotic agent, analyzed the characteristics and advantages and disadvantages, and summarized several non-drug neuroprotective therapies.
Key words:  ischemic stroke  neuroprotection  reperfusion injury  antioxidants