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  • 黄若尘,苏永华,苟浩,李威.基于复方抑瘤机制的新型纳米中药胶束剂型设计[J].第二军医大学学报,2019,40(8):821-826    [点击复制]
  • HUANG Ruo-chen,SU Yong-hua,GOU Hao,LI Wei.Design of novel micellar nano-traditional Chinese medicine formulations based on anti-tumor mechanisms of traditional composition[J].Acad J Sec Mil Med Univ,2019,40(8):821-826   [点击复制]
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基于复方抑瘤机制的新型纳米中药胶束剂型设计
黄若尘1,苏永华1,2*,苟浩2,李威3*
0
(1. 上海中医药大学研究生院, 上海 201203;
2. 海军军医大学(第二军医大学)长海中医医院, 上海 200433;
3. 海军军医大学(第二军医大学)纳米医学研究室, 上海 200433
*通信作者)
摘要:
临床实践证明中药复方具有明显的抗肿瘤作用,深入探讨中药复方有效成分的抗肿瘤作用及其对靶细胞的作用机制,对开发新的纳米中药制剂和临床中西医结合治疗肿瘤有着重要意义。本文概述了中药复方的抗肿瘤研究进展及单味中药的抗肿瘤机制,并在此基础上总结分析了目前传统纳米中药剂型的研究进展,然后以中药紫草中的紫草素为例阐述如何根据单味中药的作用机制,利用纳米材料和纳米自组装技术,围绕临床治疗中的难点设计新型纳米高分子中药剂型。
关键词:  抗肿瘤药(中药)  复方  纳米技术  纳米中药胶束剂型
DOI:10.16781/j.0258-879x.2019.08.0821
投稿时间:2019-06-26修订日期:2019-07-25
基金项目:国家自然科学基金(8167140246,31470964).
Design of novel micellar nano-traditional Chinese medicine formulations based on anti-tumor mechanisms of traditional composition
HUANG Ruo-chen1,SU Yong-hua1,2*,GOU Hao2,LI Wei3*
(1. Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
2. Changhai Traditional Chinese Medicine Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
3. Laboratory of Nano Biomedicine, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding authors)
Abstract:
Clinically traditional Chinese medicine (TCM) has been proven to possess obvious anti-tumor effects. It is critical to further explore the effective components and the corresponding mechanism of the TCM against target cells, which also has great significance for developing novel nano-TCM formulations for clinical treatment of tumor. This paper systematically reviews the anti-tumor effects of Chinese herbal compound and the anti-tumor mechanism of single herb. We also summarized the progress in the current traditional nano-TCM preparations. Taking the shikonin in Herba Arnebiae as an example, using the nano-material self-assembly technology, we discussed the design of novel nano-macromolecule TCM formulations while considering the mechanism of single herb and the clinical obstacles.
Key words:  antineoplastic drugs (TCD)  compounds (TCD)  nanotechnology  micellar nano-formulation of traditional Chinese medicine