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  • 吉进,王富博,孙颖浩*.外泌体在前列腺癌进展中的作用[J].第二军医大学学报,2018,39(7):704-710    [点击复制]
  • JI Jin,WANG Fu-bo,SUN Ying-hao*.Role of exosomes in progression of prostate cancer[J].Acad J Sec Mil Med Univ,2018,39(7):704-710   [点击复制]
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外泌体在前列腺癌进展中的作用
吉进,王富博,孙颖浩*
0
(海军军医大学(第二军医大学)长海医院泌尿外科, 上海 200433
*通信作者)
摘要:
前列腺癌细胞主动分泌的外泌体是前列腺肿瘤细胞与间质细胞间信息传递的媒介,其通过改变原发灶和转移灶的微环境促进前列腺癌进展。具体而言,外泌体是通过其携带的具有生物活性的物质,如RNA、蛋白质等参与前列腺癌进展相关的分子事件。因此,在临床上,外泌体及其内容物有望成为预测前列腺癌进展的新型分子标志物和干预靶点。近年来,前列腺癌外泌体领域的相关研究逐年增多,并在预测前列腺癌进展方面显示出巨大价值,本文对此进行综述。
关键词:  外泌体  前列腺肿瘤  肿瘤进展  肿瘤转移
DOI:10.16781/j.0258-879x.2018.07.0704
投稿时间:2018-04-15修订日期:2018-06-12
基金项目:国家自然科学基金(81430058).
Role of exosomes in progression of prostate cancer
JI Jin,WANG Fu-bo,SUN Ying-hao*
(Department of Urology, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Exosomes actively secreted by prostate cancer cells are mediators of signal transduction between prostate tumor cells and mesenchymal cells, and they can promote the progress of prostate cancer by altering the microenvironment of primary tumors and metastasis tumors. In particular, exosomes participate in various molecular events related to prostate cancer progress by carrying bioactive molecules, such as RNAs and proteins. Therefore, exosomes and their carrying molecules are expected to be novel biomarkers for predicting the progress of prostate cancer and therapeutic targets of prostate cancer. In recent years, there are many researches in the field of prostate cancer-derived exosomes which have shown great values in predicting and preventing the progress of prostate cancer, and this review sums up the current advances.
Key words:  exosomes  prostatic neoplasms  neoplasm progress  neoplasm metastasis