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  • 姚彤,许文萍,陈若华.儿童哮喘的表型分析研究进展[J].第二军医大学学报,2018,39(6):651-656    [点击复制]
  • YAO Tong,XU Wen-ping,CHEN Ruo-hua.Analysis of asthma phenotypes in children: an update[J].Acad J Sec Mil Med Univ,2018,39(6):651-656   [点击复制]
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儿童哮喘的表型分析研究进展
姚彤1,许文萍2,陈若华3*
0
(1. 海军军医大学(第二军医大学)长海医院儿科, 上海 200433;
2. 新疆维吾尔自治区人民医院儿科, 乌鲁木齐 830001;
3. 海军军医大学(第二军医大学)长海医院特需诊疗科, 上海 200433
*通信作者)
摘要:
哮喘是儿童期常见的炎性疾病,基因、环境、宿主因素的相互作用促成了哮喘的发生和发展。哮喘的异质性导致哮喘表型分类的复杂性。本文对近期儿童哮喘表型的分析方法进行综述,从发病年龄、喘息模式、临床特征、气道炎性细胞、危险因素、免疫、遗传等角度探讨儿童哮喘表型的分析方法,并对以往的哮喘表型进行预后评估,以期为哮喘患儿治疗及预后的相关性研究提供依据。
关键词:  哮喘  儿童  表型  喘息模式
DOI:10.16781/j.0258-879x.2018.06.0651
投稿时间:2017-09-04修订日期:2017-11-24
基金项目:
Analysis of asthma phenotypes in children: an update
YAO Tong1,XU Wen-ping2,CHEN Ruo-hua3*
(1. Department of Pediatrics, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Pediatrics, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China;
3. Department of VIP Medicine, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author)
Abstract:
Asthma is a common inflammatory disease in childhood. The interaction of genes, environment and host factors contributes to the development and progression of asthma, and the heterogeneity of asthma leads to the complexity of asthma phenotype classification. In this article, we reviewed recent analyses of asthma phenotypes in children using different criteria, including the age of onset, breathing pattern, clinical characteristics, airway inflammatory cells, risk factors, immunity and genetics, and assessed the prognosis of previous asthma phenotypes based on the above criteria, hoping to provide evidence for the treatment and prognosis of children with asthma.
Key words:  asthma  child  phenotypes  breathing pattern