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  • 焦秀秀,丁雪鹰*.纳米载药系统靶向治疗脑胶质瘤的策略[J].第二军医大学学报,2017,38(7):910-917    [点击复制]
  • JIAO Xiu-xiu,DING Xue-ying*.Targeted therapy strategies of nano drug delivery system for malignant glioma[J].Acad J Sec Mil Med Univ,2017,38(7):910-917   [点击复制]
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纳米载药系统靶向治疗脑胶质瘤的策略
焦秀秀,丁雪鹰*
0
(上海交通大学附属第一人民医院临床药学科, 上海 200080
*通信作者)
摘要:
脑胶质瘤是一类恶性程度非常高的肿瘤,常规治疗仅对患者肿瘤进展和总生存期略有改善,急需寻找新的治疗方法。近年来随着纳米技术的不断发展,纳米载体促使药物跨越血脑屏障和脑内转运成为可能,结合迅速发展的靶向治疗策略,通过纳米载药系统靶向脑胶质瘤上的具体靶点,可提高治疗药物的抗胶质瘤效果。本文主要综述几种纳米载体策略在靶向治疗脑胶质瘤中的研究进展。
关键词:  脑肿瘤  胶质母细胞瘤  血脑屏障  纳米技术药物释放系统  靶向治疗
DOI:10.16781/j.0258-879x.2017.07.0910
投稿时间:2016-10-30修订日期:2017-04-15
基金项目:国家自然科学基金(81472349),上海市自然科学基金(14ZR1433300).
Targeted therapy strategies of nano drug delivery system for malignant glioma
JIAO Xiu-xiu,DING Xue-ying*
(Department of Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China
*Corresponding author)
Abstract:
Malignant glioma is a kind of highly malignant tumor. Since routine therapeutic approaches can only improve the total survival time of the patients with malignant glioma and delay the tumor progression, so the investigation of novel therapies is urgent. With the development of nanotechnology, the nanocarriers for delivering drugs make it possible to transport drugs across the blood brain barrier. Nano drugs delivery system can allow the drugs directly act on the specific targets of malignant glioma combining with rapidly developing targeted therapy strategies, which has improved the therapeutic efficacy of tumor. In this review, we focused on the advances of several nano drug delivery strategies for targeted treating of malignant glioma.
Key words:  brain neoplasms  glioblastoma  blood-brain barrier  nanotechnology drug delivery system  targeting therapy