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  • 王洪祥,秦荣,符达,陈菊祥.二代测序在胶质瘤研究与个体化治疗中的应用[J].第二军医大学学报,2017,38(8):1046-1052    [点击复制]
  • WANG Hong-xiang,QIN Rong,FU Da,CHEN Ju-xiang.Application of next-generation sequencing in research and personalized treatment of glioma[J].第二军医大学学报,2017,38(8):1046-1052   [点击复制]
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二代测序在胶质瘤研究与个体化治疗中的应用
王洪祥1,秦荣2,符达3,陈菊祥1*
0
(1. 第二军医大学长征医院神经外科, 上海市神经外科研究所, 全军神经外科研究所, 上海 200003;
2. 解放军184医院神经外科, 鹰潭 335000;
3. 中国科学院上海生物科学研究所健康科学研究所, 上海 200032
*通信作者)
摘要:
脑胶质瘤是一类高度致死性恶性肿瘤,目前有关其在基因组学的研究及临床治疗存在诸多挑战。二代测序技术具有高通量优势,能通过对肿瘤全基因组、外显子组、转录组及表观遗传组全面分析加深对肿瘤基因组学的认识,并已成功应用于部分肿瘤的临床研究中,为肿瘤个体化靶向治疗提供合适可行的指导。当前,运用二代测序研究胶质瘤已成为热点,将全面阐明胶质瘤致病机制,并为制定个体化治疗方案提供策略,使患者获益。
关键词:  脑肿瘤  胶质瘤  DNA序列分析  个体化治疗
DOI:10.16781/j.0258-879x.2017.08.1046
投稿时间:2016-12-20最后修改时间:2017-05-14
基金项目:国家自然科学基金(81272781),上海市卫生系统优秀学科带头人新百人计划(XBR02011030),上海市曙光学者计划(11SG37).
Application of next-generation sequencing in research and personalized treatment of glioma
WANG Hong-xiang1,QIN Rong2,FU Da3,CHEN Ju-xiang1*
(1. Department of Neurosurgery, Shanghai Institute of Neurosurgery, Neurosurgery Institute of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;
2. Department of Neurosurgery, No. 184 Hospital of PLA, Yingtan 335000, Jiangxi, China;
3. Institute of Health Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
*Corresponding author)
Abstract:
Glioma is a highly lethal malignancy and multiple challenges remain for it in the genomic study and clinical treatment. Next-generation sequencing (NGS) holds many advantages, and NGS can comprehensively analyze the whole genome, exome, transcriptome and epigenome to deepen the understanding of tumor genomics; and now, it has been successfully applied in the clinical study of some tumors, especially in personalized treatment for these tumors. At present, NGS has also been a hot in glioma research to clarify the pathogenesis of glioma, so as to draw up a personalized treatment method to benefit the patients.
Key words:  brain neoplasms  glioma  DNA sequence analysis  personalized treatment