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  • 邹丹,金戈.大鼠在适应新的感觉配置后海马CA1位置细胞的集群放电[J].第二军医大学学报,2014,35(6):592-597    [点击复制]
  • zoudan,jinge.Discharges of place cell assembly of hippocampus CA1 after the adaptation of new sensory configuration in rat[J].Acad J Sec Mil Med Univ,2014,35(6):592-597   [点击复制]
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大鼠在适应新的感觉配置后海马CA1位置细胞的集群放电
邹丹,金戈
0
(沈阳医学院病理生理教研室;沈阳医学院药理教研室)
摘要:
[摘要] 目的 观察大鼠经过学习其海马结构接受视觉-前庭-本体感觉错配格局并将其视为匹配的状态后CA1位置细胞的电活动,为揭示海马结构可编码感觉输入的任何组合提供依据。方法 建立视觉-前庭-本体感觉错配格局,根据对海马结构齿状回θ节律的记录及其电功率的计算,获知大鼠适应该感觉冲突后,应用钨丝微电极细胞外记录方法,记录清醒大鼠在适应视觉-前庭-本体感觉错配条件后海马结构CA1位置细胞神经元集群放电情况。结果56个位置细胞中,14个神经元在感觉正配及错配条件下均有位置稳定的空间放电(双向移动相关-经验非依赖神经元),33个神经元在感觉正配及错配条件下依次出现位置不稳的空间放电(双向移动相关-经验依赖神经元)。经验非依赖神经元的位置野长度及非对称指数的均值显著大于经验依赖型神经元。此外,位置野内放电频率的分布呈现出不对称及负偏斜。结论 动物在适应自然情况下不可能出现的新的感觉配置后,海马结构能编码这一配置并能更新它储存的记忆,接受新的配置作为匹配状态。海马结构可能编码感觉输入的任何组合。
关键词:  新的感觉错配  适应  海马  位置细胞  神经元放电
DOI:10.3724/SP.J.1008.2014.00592
投稿时间:2013-12-28修订日期:2014-05-19
基金项目:留学回国人员科研启动基金
Discharges of place cell assembly of hippocampus CA1 after the adaptation of new sensory configuration in rat
zoudan,jinge
()
Abstract:
[Abstract] Objective To study the discharge change of CA1 place cell after hippocampal formation(HF)accepting the visual-vestibular-proprioceptive mismatch configuration as a match by learning, which could provide new scientific experimental data for revealing the fact that HF may encode any combination of sensory inputs. Methods The visual-vestibular-proprioceptive mismatch configuration was set up. According to theta rhythm recording and theta power calculation in rat hippocampal dentate gyrus, it was acquainted that the rat had been adaptive to the sensory conflict. The assembly discharge of CA1 area place cell was recorded in awake rat by using extracellular tungsten microelectrode record and stereotaxic techniques after the rat adapted to sensory mismatch. Results Out of 56 place cells, 14 showed consistent spatial firing in both the match and mismatch condition (both translocation-related experience-independent neurons). 33 showed different spatial firings across the sessions (both translocation-related experience-dependent neurons). The mean sizes of the place fields were larger in both translocation-related neurons than that of experience-dependent neurons. The firing rate distributions in the place fields were negatively skewed and asymmetric. Conclusion The HF encodes a naturally impossible new configuration of sensory inputs after adaptation, the HF is capable of updating it stored memory to accept a new configuration as a match. The HF may encode any combination of sensory inputs.
Key words:  New sensory configuration  adaptation  hippocampus  place cell  neuron discharge