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  • 张姗姗,王彦,李德东,曹永兵,姜远英.NADH和NADPH代谢和功能的研究进展[J].第二军医大学学报,2011,32(11):1239-1243    [点击复制]
  • ZHANG Shan-shan,WANG Yan,LI De-dong,CAO Yong-bing,JIANG Yuan-ying.Metabolism and function of NADH and NADPH[J].Acad J Sec Mil Med Univ,2011,32(11):1239-1243   [点击复制]
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NADH和NADPH代谢和功能的研究进展
张姗姗,王彦,李德东,曹永兵,姜远英*
0
(第二军医大学药学院新药研究中心,上海 200433
共同第一作者.
*通信作者)
摘要:
近年来的研究发现,NADH和NADPH在机体生理与病理条件下都发挥重要的功能,本文综述了NADH和NADPH的合成和降解,重点阐述了NADH、NADPH和NADPH氧化酶的功能,并按炎症、心血管疾病、肿瘤、神经退行性疾病等不同病理状况分别叙述。当前对细胞内NADH(NADPH)作用和代谢的研究已成为国际性的研究热点,其相关机制的探讨将逐步深入。
关键词:  NAD  NADP  代谢  功能
DOI:10.3724/SP.J.1008.2011.01239
投稿时间:2011-03-19修订日期:2011-06-11
基金项目:国家自然科学基金(81072678,30825041,30630071,30672626), 上海市教育发展基金会晨光计划(2007CG51), 国家科技部科技重大专项(2011ZX09102-002-01), 上海市科委科技重点项目(10431902200).
Metabolism and function of NADH and NADPH
ZHANG Shan-shan,WANG Yan,LI De-dong,CAO Yong-bing,JIANG Yuan-ying*
(Research and Development Center of New Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Co-first authors.
*Corresponding author.)
Abstract:
In recent years, researchers have discovered that NADH and NADPH have important functions in physiological and pathological conditions. In this paper we discussed the synthesis and degradation of NADH and NADPH, focused on the function of NADH, NADPH and NADPH oxidase, and described their functions in various pathological conditions such as inflammation, cardiovascular disease, cancer, neurodegenerative diseases. Nowadays, the functions and metabolism of NADH (NADPH) have evoked international research interest; and the underlying mechanism will be better understood.
Key words:  NAD  NADP  metabolism  function