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  • 曹大鹏1,2,韩婷1,郑毅男2,秦路平1,张巧艳1*.仙茅的酚苷和木脂素类成分的分离和鉴定[J].第二军医大学学报,2009,30(2):194-197    [点击复制]
  • CAO Da-peng1, 2,HAN Ting1,ZHENG Yi-nan2,QIN Lu-ping1,ZHANG Qiao-yan1*.Phenolic glycosides and lignans components in Curculigo orchioides Gaertn[J].Acad J Sec Mil Med Univ,2009,30(2):194-197   [点击复制]
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仙茅的酚苷和木脂素类成分的分离和鉴定
曹大鹏1,2,韩婷1,郑毅男2,秦路平1,张巧艳1*
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(1.第二军医大学药学院生药学教研室,上海 200433*2.吉林农业大学中药材学院中药化学教研室,长春 130118)
摘要:
目的:分离鉴定仙茅Curculigo orchioides Gaertn.的酚苷和木脂素类成分。方法:利用硅胶和Sephadex LH-20凝胶柱层析,以及半制备HPLC方法分离化学成分,通过理化性质和光谱方法确定所分离化合物的结构。结果:仙茅乙醇提取物中得到5个酚苷类成分,1个木脂素类成分,1个甾醇类成分。经鉴定分别为2,6-二甲氧基苯甲酸(1)、仙茅苷(2)、仙茅苷乙(3)、仙茅素A(4)、2,4-二氯-5-羟基-3-甲基苯酚-1-O-β-D-吡喃葡萄糖-(1→6)-β-D-吡喃葡萄糖苷(5)、3,3′,5,5′-四甲氧基-7,9′7′,9-二环氧木脂素-4,4′-二-O-β-D-葡萄糖苷(6)、β-谷甾醇(7)。结论:从仙茅乙醇提取物中分离出7个化合物,其中化合物(5)为一新的含氯酚类成分,命名为仙茅素D。
关键词:  仙茅    酚苷  木脂素  仙茅素D
DOI:10.3724/SP.J.1008.2009.00194
投稿时间:2008-07-19修订日期:2008-12-09
基金项目:国家自然科学基金(90209043).
Phenolic glycosides and lignans components in Curculigo orchioides Gaertn
CAO Da-peng1, 2,HAN Ting1,ZHENG Yi-nan2,QIN Lu-ping1,ZHANG Qiao-yan1*
(1.Department of Pharmacognosy,School of Pharmacy,Second Military Medical University,Shanghai 200433,China*2.Department of Traditional Chinese Medicine Chemistry,College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118)
Abstract:
Objective:To isolate and identify phenolic glycosides and lignans from the rhizomes of Curculigo orchioides Gaertn.Methods: Phenolic glycosides and lignans were isolated by silica gel,Sephadex LH-20 chromatography and semi-preparative HPLC methods.The structures of the isolated compounds were identified by physiochemical and spectral analysis/Results: Five phenolic glycosides,one lignan and one sitosterol were isolated and identified from Curculigo orchioides Gaertn,namely, 2,6-dimethoxy benzolic acid(1),curculigoside A(2),curculigoside B(3),curculigine A(4),4-dichlorine-5-hydroxyl-3-methylphenol-1-O-β-D-glucopyranosyl-(1→6)-β-D-gluco-pyranosede(5),3,3′,5,5′-tetramethoxy-7,9′:7′,9 -diepoxylignan -4,4′-di-O-β-D-glucopyranoside(6),and β-sitosterol(7).Conclusion: Seven compounds have been isolated from Curculigo orchioides Gaertn; compound 5 is a new chlorine-containing phenol,and is named as curculigine D.
Key words:  Curculigo orchioides Gaertn.  phenol  phenolic glycosides  lignan  curculigine D